Autoantibodies (AAbs) are antibodies that are produced by the B-cell immune system against individual’s own antigens (AAgs) and play pivotal roles in the maintenance of healthy individuals’ homeostasis, as well as in tumors and autoimmune diseases. In the past 70 years, tremendous efforts have been devoted to elucidate the generation, evolution and function of AAbs and their targets, AAgs. However, the comprehensive study of AAb in human diseases has remained as a challenge due to the distribution of these AAgs in literature randomly. Here we present an AAg Atlas portal containing 8, 045 well-annotated AAgs, 47 post-translational modification related AAgs and 1,090 related human diseases, which were determined by text-mining, statistical analysis and manual curation of 141,473 PubMed abstracts, 1,018 full-text articles and 227 microarray datasets. AAg Atlas portal provides a user-friendly interface to conveniently browse, retrieve and download the list of human AAgs and associated diseases as well as to execute functional analysis through Expression Atlas and Reactome. This portal is freely accessible at http://biokb.ncpsb.org/aagatlas_portal/.

Reference:
Wang, D., Yang, L., Zhang, P., LaBaer, J., Hermjakob, H., Li, D., and Yu, X. (2017) AAgAtlas 1.0: a human autoantigen database. Nucleic Acids Res 45, D769-D776.