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GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	METAP2 (HGNC Symbol)
Synonyms	MAP2, MNPEP, p67
Description	Methionyl aminopeptidase 2 (HGNC Symbol)
Entrez gene summary	This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q22
Chromosome location (bp)	95473520 - 95515839
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111142 (version 78.38)
Entrez gene	10988
UniProt	P50579 (UniProt - Evidence at protein level)
neXtProt	NX_P50579
Antibodypedia	METAP2 antibodies