Generated by the humoral immune system, antibodies are capable of specifically binding to virtually any biomolecule target (broadly termed “antigens”). Although the primary function of antibodies is to provide adaptive immunity against pathogens, invariably some antibodies arise that bind to self-antigens. These autoantibodies elicit a wide range of biological effects, including altering the activity of their targets and immunomodulation. Every person carries a distinct array of auto-antibodies—an“autoantibody reactome”—offering a potential avenue for trait diversity that mirrors the way genetic differences influence phenotypes. （Science. 2024 ）

In our previous work, we developed an AAg Atlas portal containing 8, 045 well-annotated AAgs, 47 post-translational modification related AAgs and 1,090 related human diseases, which were determined by text-mining, statistical analysis and manual curation of 141,473 PubMed abstracts, 1,018 full-text articles and 227 microarray datasets. (Nucleic Acids Res 2017, J Proteome Res 2023 ). Furthermore, we developed the first AI-driven proteome microarray platform according to AAgAtlas 1.0 database, which can determine more than 3,000 autoantibody molecules with only 1/10 drop of blood. The utility of AAgAtlas 1.0 microarray has been widely applied into the identification of biomarkers, target of therapeutic targets as well as vaccine development, etc. (Annals of the Rheumatic Diseases,2025)

Selected references:
1. Jaycox JR, Dai Y, Ring AM. Decoding the autoantibody reactome. Science. 2024 383(6684):705-707.
2. Wang, D., Yang, L., Zhang, P., LaBaer, J., Hermjakob, H., Li, D., and Yu, X. (2017) AAgAtlas 1.0: a human autoantigen database. Nucleic Acids Res 45, D769-D776.
3. Wang D, Yang D, Yang L, Diao L, Zhang Y, Li Y, Wang H, Ren J, Cheng L, Tan Q, Zhang R, Han X, Zhang X, Wang B, Li D, Chen M, Hermjakob H, Li Y, LaBaer J, Zhou Z, Yu X.J Proteome Res. 2023 22(6):1800-1815.