PDCD1

GENE INFORMATIONi

Gene name

PDCD1 (HGNC Symbol)

Synonyms

CD279, hSLE1, PD-1, PD1, SLEB2

Description

Programmed cell death 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q37.3

Chromosome location (bp)

241849881 - 241858908

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000188389 (version 83.38)

Entrez gene

5133

UniProt

Q15116 (UniProt - Evidence at protein level)

neXtProt

NX_Q15116

Antibodypedia

PDCD1 antibodies