IL2

Validated evidence

" Use of anti-IL-2 receptor antibody as a part of maintenance immunosuppression may be beneficial in liver-excluding transplants. "    
Provided by Pubmed

Gene name

IL2 (HGNC Symbol)

Synonyms

IL-2, TCGF

Membrane Protein ?

-

Disease section

Description

Interleukin 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q27

Chromosome location (bp)

122451470 - 122456725

Ensembl

ENSG00000109471 (version 83.38)

Entrez gene

3558

UniProt

P60568 (UniProt - Evidence at protein level)

neXtProt

NX_P60568

Antibodypedia

IL2 antibodies