HLA-G

GENE INFORMATIONi

Gene name

HLA-G

Synonyms

Description

Major histocompatibility complex, class I, G (HGNC Symbol)

Entrez gene summary

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p22.1

Chromosome location (bp)

29826967 - 29831125

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000204632 (version 83.38)

Entrez gene

3135

UniProt

P17693 (UniProt - Evidence at protein level)

neXtProt

NX_P17693

Antibodypedia

HLA-G antibodies