CAV1

GENE INFORMATIONi

Gene name

CAV1 (HGNC Symbol)

Synonyms

CAV

Description

Caveolin 1, caveolae protein, 22kDa (HGNC Symbol)

Entrez gene summary

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]

Chromosome

7

Cytoband

q31.2

Chromosome location (bp)

116524785 - 116561184

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105974 (version 83.38)

Entrez gene

857

UniProt

Q03135 (UniProt - Evidence at protein level)

neXtProt

NX_Q03135

Antibodypedia

CAV1 antibodies